CAS RN 838818-26-1
IUPAC Nombre:
3-(3-{[4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}propyl)-3-azatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-2,4-dione
Sinónimos:
3-(3-{[4-(4-methoxyphenyl)-5-(pyridin-4-yl)-1,2,4-triazol-3-yl]sulfanyl}propyl)-3-azatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-2,4-dione
Peso molecular (g/mol):
521.6
Fórmula molecular:
C29H23N5O3S
InChi Key:
RNUXIZKXJOGYQP-UHFFFAOYSA-N
SMILES:
COC1=CC=C(C=C1)N1C(SCCCN2C(=O)C3=CC=CC4=CC=CC(C2=O)=C34)=NN=C1C1=CC=NC=C1
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Tocris Bioscience™ WIKI4
Potent tankyrase inhibitor
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WIKI4, MedChemExpress
MedChemExpress WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM.
