CAS RN 196868-63-0
IUPAC Nombre:
1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea
Sinónimos:
1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea
Peso molecular (g/mol):
341.8
Fórmula molecular:
C18H16ClN3O2
InChi Key:
YBLWOZUPHDKFOT-UHFFFAOYSA-N
SMILES:
COC1=C(NC(=O)NC2=C3C=CC=CC3=NC(C)=C2)C=C(Cl)C=C1
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1
Tocris Bioscience™ PQ 401
CAS: 196868-63-0 Fórmula molecular: C18H16ClN3O2
2
PQ401, MedChemExpress
MedChemExpress PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis.
