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CH3H3CNHNOHNCH3H3CCH3ONNNH2NBrOHOH

CAS RN 1561178-17-3

IUPAC Nombre: 3-(3-{[(5-{4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-3,4-dihydroxyoxolan-2-yl)methyl](propan-2-yl)amino}propyl)-1-(4-tert-butylphenyl)urea
Sinónimos: 3-(3-{[(5-{4-amino-5-bromopyrrolo[2,3-d]pyrimidin-7-yl}-3,4-dihydroxyoxolan-2-yl)methyl](isopropyl)amino}propyl)-1-(4-tert-butylphenyl)urea
Peso molecular (g/mol): 618.58
Fórmula molecular: C28H40BrN7O4
InChi Key: IQCKJUKAQJINMK-UHFFFAOYNA-N
SMILES: CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC1OC(C(O)C1O)N1C=C(Br)C2=C(N)N=CN=C12
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1

SGC-0946, TRC

CAS: 1561178-17-3 Fórmula molecular: C28H40BrN7O4 Peso molecular (g/mol): 618.57 Sinónimo: SGC-0946,5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Nombre IUPAC: 1-[3-[[(2R,3S,4R,5R)-5-(4-amino-5-bromopyrrolo[2,3-d]pirimidina-7-il)-3,4-dihidroxioxilán-2-il]metil-propano-2-ilamino]-3-(4-tert-butilfenil)urea SMILES: CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n3cc(Br)c4c(N)ncnc34

Sinónimo SGC-0946,5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Fórmula molecular C28H40BrN7O4
CAS 1561178-17-3
Peso molecular (g/mol) 618.57
SMILES CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n3cc(Br)c4c(N)ncnc34
Nombre IUPAC 1-[3-[[(2R,3S,4R,5R)-5-(4-amino-5-bromopyrrolo[2,3-d]pirimidina-7-il)-3,4-dihidroxioxilán-2-il]metil-propano-2-ilamino]-3-(4-tert-butilfenil)urea
2

Tocris Bioscience™ SGC 0946
GREENER_CHOICE

Highly potent and selective DOT1L inhibitor; cell permeable

3

SGC0946, MedChemExpress

MedChemExpress SGC0946 is a selective DOT1LH3K79 methyltransferase) inhibitor, with an IC50 of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of DOT1L in both normal and diseased cells.

ENCOMPASS_PREFERRED
Información de solubilidad DMSO : 50 mg/mL (80.83 mM; Need ultrasonic)
Forma física Solid
Almacenamiento recomendado Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Peligro para la salud 1 H301
Color Light Nude
SMILES NC1=NC=NC2=C1C(Br)=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN(CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)C(C)C)O3
Notas de grado de pureza Research
Duración de almacenamiento Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Formula Weight (peso de la fórmula) 618.57
Fórmula molecular C28H40BrN7O4
CAS 1561178-17-3
Nombre del producto químico o material SGC0946
Porcentaje de pureza 98.0%
Peso molecular (g/mol) 618.57
Grado Research
Para utilizar con (aplicación) Cancer-programmed cell death