CAS RN 134308-13-7
IUPAC Nombre:
5-(4-methylbenzoyl)-3-nitrobenzene-1,2-diol
Sinónimos:
tolcapone tasmar
Peso molecular (g/mol):
273.24
Fórmula molecular:
C14H11NO5
InChi Key:
MIQPIUSUKVNLNT-UHFFFAOYSA-N
SMILES:
CC1=CC=C(C=C1)C(=O)C1=CC(O)=C(O)C(=C1)[N+]([O-])=O
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Thermo Scientific Chemicals Tolcapona
CAS: 134308-13-7 Fórmula molecular: C14H11NO5 Peso molecular (g/mol): 273.24 Clave InChI: MIQPIUSUKVNLNT-UHFFFAOYSA-N Nombre IUPAC: 5-(4-metilbenzoil)-3-nitrobenceno-1,2-diol SMILES: CC1=CC=C(C=C1)C(=O)C1=CC(O)=C(O)C(=C1)[N+]([O-])=O
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Tocris Bioscience™ Tolcapona
COMT inhibitor; also inhibits transthyretin aggregation
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Tolcapone, MedChemExpress
MedChemExpress Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.
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