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  6. Scopolamine hydrobromide trihydrate, 99%

Scopolamine hydrobromide trihydrate, 99%

Product Code. 10117943 Shop All Thermo Scientific Chemicals Products
1 g, Glass bottle, 1g
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Quantity:
1 g
5 g
25 g
Packaging:
Glass bottle
Unit Size:
1g
25g
5g
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Description

Scopolamine hydrobromide trihydrate, CAS # 6533-68-2, is the trihydrate form of scopolamine hydrobromide that shows competitive anti-muscarinic activity by blocking the actions of endogenous acetylcholine or exogenous agonists. It also shows anti-spasmodic and anti-emetic activities. | CAS: 6533-68-2 | C17H28BrNO7 | 438.32 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Scopolamine hydrobromide trihydrate is a salt form of scopolamine, a tropane alkaloid derived from plants of the nightshade family (Solanaceae), mainly Hyoscyamus niger and Atropa belladonna
• Scopolamine hydrobromide trihydrate, demonstrates competitive anti-muscarinic activity blocking the actions of endogenous acetylcholine or exogenous agonists
• It also shows anti-spasmodic and anti-emetic activities

Applications

• It has been described that scopolamine inhibits muscarinic acetylcholine receptors (mAChRs) with some selectivity for M1 mAChRs
• It is structurally similar to acetylcholine and can antagonize acetylcholine activity mediated by muscarinic receptors located on structures innervated by postganglionic cholinergic nerves and on smooth muscles (that respond to acetylcholine but lack cholinergic innervation)
• Scopolamine hydrobromide trihydrate can induce amnesia in laboratory animals and so it is frequently used in animal models of memory deficit
• Scopolamine hydrobromide trihydrate is used to induce cognitive deficits in animal models of Alzheimer’s disease
• Scopolamine, has been employed in several studies to understand, identify, and characterize biological targets for Alzheimer's disease

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 6533-68-2
Molecular Formula C17H28BrNO7
Molecular Weight (g/mol) 438.32
MDL Number MFCD00150066
InChI Key LACQPOBCQQPVIT-FCFGRTKISA-N
Synonym hyoscine hydrobromide trihydrate
PubChem CID 131632304
IUPAC Name hydrogen (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0²,⁴]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate bromide
SMILES [H+].O.O.O.[Br-].CN1[C@H]2CC(C[C@H]1[C@@H]1O[C@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1

Specifications

Melting Point 194.0°C to 197.0°C
Color White or Colorless
Infrared Spectrum Authentic
Assay Percent Range 99%
Packaging Glass bottle
Quantity 1 g
Beilstein 27, 102
Merck Index 14, 8406
Specific Rotation Condition −27° (20°C c=5,H2O)
Specific Rotation − 27.00
Solubility Information Solubility in water: 700g/L water (20°C). Other solubilities: 1g/20 mL alcohol,slightly soluble in chloroform,practically insoluble in ether
Formula Weight 438.3
Percent Purity 99%
Physical Form Crystalline Powder or Crystals
Chemical Name or Material Scopolamine hydrobromide trihydrate, 99%
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Safety and Handling

compliance-icons
Product Identifier
  • Scopolamine hydrobromide trihydrate
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 1
  • Acute toxicity Category 2
 Hazard Statement
  • H310-Fatal in contact with skin.
  • H330-Fatal if inhaled.
  • H300-Fatal if swallowed.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
  • P302+P352-IF ON SKIN: Wash with plenty of water/.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P310-Immediately call a POISON CENTER/doctor/.
  • P361-Take off immediately all contaminated clothing.
SDS

RUO – Research Use Only

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