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  6. GSK-3β Mouse, Unlabeled, Clone: 7, BD

GSK-3β Mouse, Unlabeled, Clone: 7, BD

Product Code. 15855329
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Quantity:
150 μg
50 μg
Unit Size:
1 set
Each
Product Code. Quantity unitSize
15855329 50 μg 1 set
15371687 150 μg Each
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This item is not returnable. View return policy

Product Code. 15855329

Brand: BD Biosciences 610201

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Description

Mouse Monoclonal Antibody

Glycogen Synthase Kinase-3β (GSK-3β) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and, thus, down-regulating the activity of muscle glycogen synthase. GSK-3β is identical to the Tau Protein Kinase 1 (TPK 1) which plays a role in the formation of the histopathological lesions of Alzheimer's disease (AD). In AD, many neurons contain intracytoplasmic neurofibrillary tangles (NFT) that are composed of ubiquitin and highly phosphorylated tau proteins, members of a family of microtubule-assocaited phosphoproteins. Phosphorylation of the tau proteins by GSK-3β converts them into paired helical filaments (PHF) which are found in NFT and degenerative neurites of senile plaques. This ability of GSK-3β to convert tau proteins to PHF has been demonstrated in vitro using primary cultures of embryonic rat hippocampal neurons.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen GSK-3β
Applications Western Blot
Classification Monoclonal
Clone 7
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat GSK-3β aa. 1-160
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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