CAS RN 148741-30-4
IUPAC Nombre:
(2E)-3-amino-2-[(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile
Sinónimos:
(2E)-3-amino-2-[(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile
Peso molecular (g/mol):
316.46
Fórmula molecular:
C18H24N2OS
InChi Key:
LCUMYVYIHXYBIA-FOWTUZBSSA-N
SMILES:
CC(C)(C)C1=CC(=C\C(C#N)=C(\N)S)C=C(C1=O)C(C)(C)C
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Tyrphostin AG 879, MedChemExpress
MedChemExpress Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity.
