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von Hippel-Lindau (vHL) Protein Ab-1, Mouse Monoclonal Antibody,Lab Vision™ Epredia™

Provide accurate, reproducible results with the Epredia™ von Hippel-Lindau (vHL) Protein Ab-1, Mouse Monoclonal Antibody.

Marca:  Epredia MS-690-PABX

Detalles adicionales : Peso : 1.00000kg

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Código de producto. 12692037

  • 630.00€ / 200 microlitros

Envío estimado: 02-07-2021

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Descripción

Descripción

Molecular genetic studies suggest that VHL is a tumor-suppressor gene. Alterations in the von Hippel-Lindau (VHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC), and pheochromocytoma. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation.

Host Species: Mouse

Clone: Ig33

Isotype: IgG1/κ

Species Reactivity: Human and Mouse. Others not known.

Epitope: aa 1-54

Immunogen: A recombinant protein containing aa 1-213 of human vHL

Molecular Weight: 30kDa

Positive Control: Kidney

Cellular Localization: Cytoplasmic Ab-1 does not recognize the truncated form of VHL protein.

Note:

USA: RUO; Int'l: RUO

Especificaciones

Especificaciones

von Hippel-Lindau (vHL) Protein Ab-1
Ig33
Unconjugated
Murine
IgG2a kappa
RUO
Primary
Monoclonal
Monoclonal
1mg/mL
Concentrated
A recombinant protein containing aa 1-213 of human VHL
200μL
Cancer and Tumor Biology
Primary
Human, Murine
Videos
SDS
Documentos
Certificados