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UQCRC2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 14742-1-AP-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16813544

  • 319.00€ / 150 microlitros

Envío estimado: 21-10-2021

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Descripción

Descripción

The KRAB (Kruppel-associated box) domain is about 45 amino acids in length and is a transcriptional repression domain found in numerous transcription factors. There have been identified over 220 KRAB-zinc finger protein (KRAB-ZFP) genes in the human genome. These proteins functionally repress transcription via specific interactions with KAP-1 (KRAB-associated protein 1). KAP-1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger. KAP-1 has been shown to form complexes with KRAB-domain transcription factors and increase the efficiency with which they mediate repression. KAP-1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1). KAP-1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, thus helping to regulate transcriptional repression. Studies have shown that KAP-1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.
Especificaciones

Especificaciones

UQCRC2
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P22695, P32551, Q9DB77
Complex III subunit 2, Core protein II, QCR2, UQCR2, UQCRC2
Rabbit
IgG
150 μL
-20°C
Primary
293448, 67003, 7385
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
UQCRC2
Liquid
UQCRC2
UQCRC2 Fusion Protein Ag6432
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Videos
SDS
Documentos
Certificados