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TYMS Mouse anti-Human, Clone: 1F5B7, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 66725-1-IG-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16818875

  • 319.00€ / 150 microlitros

Envío estimado: 29-10-2021

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Descripción

Descripción

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Especificaciones

Especificaciones

TYMS
1F5B7
Unconjugated
TYMS
Liquid
TYMS
TYMS Fusion Protein Ag7027
Protein G
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P04818
HsT422, Thymidylate synthase, thymidylate synthetase, TMS, TS, TSase, TYMS
Mouse
IgG1
150 μL
-20°C
Primary
7298
Videos
SDS
Documentos
Certificados