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TRAF2 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 26846-1-AP-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16815195

  • 319.00€ / 150 microlitros

Envío estimado: 21-10-2021

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Descripción

Descripción

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF2 is a 502-amino acid protein. Mutagenic studies suggest that the N-terminal RING finger and two adjacent zinc fingers of TRAF2 are required for NF-kB activation, where as interaction with TNFR is mediated through C-terminus domain. Distinct domains in the N- and -C termini are also required for association with TRAF1 and protein kinase receptor interacting protein (RIP). TRAF2 is involved in cellular resistant to TNF-induced apoptosis. TRAF-2 deficient mice appeared normal at birth, however, they die prematurely, probably due to atrophy of thymus, spleen, muscle mass and lack of TRAF-2′s cytoprotective role.
Especificaciones

Especificaciones

TRAF2
0.27 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q12933
TRAF2, TRAP, TRAP3
Rabbit
IgG
150 μL
-20°C
Primary
7186
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
TRAF2
Liquid
TRAF2
TRAF2 Fusion Protein Ag25387
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Videos
SDS
Documentos
Certificados