missing translation for 'onlineSavingsMsg'
Learn More

Tid-1 Ab-2, Mouse Monoclonal Antibody,Lab Vision™ Epredia™

Provide accurate, reproducible results with the Epredia™ Tid-1 Ab-2, Mouse Monoclonal Antibody.

Marca:  Epredia MS-1564-P1

Detalles adicionales : Peso : 1.00000kg

 Ver más versiones de este producto

Código de producto. 12689986

  • 410.00€ / 500 microlitros
Fecha estimada de envío: 17-04-2024
para ver el stock

Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.


Descripción

Descripción

TID1 is a human homolog of the Drosophila tumor suppressor lethal (2) tumerous imaginal discs, l(2)tid and encodes two mitochondrial matrix localized splice variants of human Tid-1 designated hTid-1S and hTid-1L. These proteins are the conserved members of the DnaJ family of proteins which act as cochaperons for mitochondrial Hsp70. They contain a conserved tetrahedrical J domain which binds to Hsp70 chaperones and activates their ATPase activity. Expression of hTid-1L increases apoptosis induced by DNA damaging agents as mitomycin-C and TNF-α. A J-domain mutant of hTid-1L can dominantly suppress apoptosis and in sharp contrast the J-domain mutant of hTid-1S increases apoptosis. Expression of hTid-1S and hTid-1L affects cytochrome c release from the mitochondria and caspase 3 activation, while activation of caspase 8 is unaffected. It is strongly suggested that these two splice variants exert their anti- and pro- apoptotic effects through discrete substrates and actiuvities. Hence the relative abundance of these proteins or their substrates may allow the mitochondria to dampen or enhance the apoptotic signals.

Host Species: Mouse

Clone: RS13

Isotype: IgG1/κ

Species Reactivity: Human, Mouse and Rat. Others not known.

Immunogen: Recombinant hTid-1 protein

Molecular Weight: 40 and 43kDa

Positive Control: HeLa and Jurkat cells

Cellular Localization: Mitochondria

Recommended for:

  • Western Blotting
  • Immunoprecipitation

Note:

USA: RUO; Int'l: RUO

Especificaciones

Especificaciones

Tid-1 Ab-2
Monoclonal
200μg/mL
Mouse
500 μL
Apoptosis
Human, Mouse, Rat
IgG1 κ
Immunoprecipitation, Western Blot
RS13
Unconjugated
Recombinant hTid-1 protein
RUO
Primary
Purified
Sugerencias de productos

Sugerencias de productos

Videos
SDS
Documentos

Documentos

Certificados
Ofertas especiales

Ofertas especiales