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Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody,Lab Vision™ Epredia™

Provide accurate, reproducible results Epredia™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.

Marca:  Epredia MS-471-P1

Detalles adicionales : Peso : 1.00000kg

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Código de producto. 12681537

  • 352.00€ / 500 microlitros

Envío estimado: 29-06-2021

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Descripción

Descripción

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Host Species: Mouse

Clone: TS 106

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human TS enzyme

Molecular Weight: 36kDa

Positive Control: 5-FU-resistant cell cancer lines or colon CA

Cellular Localization: Nuclear and cytoplasmic

Recommended for:

  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native verified)
  • ELISA
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Especificaciones

Especificaciones

Thymidylate Synthase Ab-1
Monoclonal
200μg/mL
Concentrated
Recombinant human TS enzyme
500μL
DNA Repair
Primary
Human
Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot
TS 106
Unconjugated
Murine
IgG2a kappa
RUO
Primary
Monoclonal
Videos
SDS
Documentos
Certificados