Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody,Lab Vision™ Epredia™
Provide accurate, reproducible results Epredia™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.
Marca: Epredia MS-471-P1
Detalles adicionales : Peso : 1.00000kg
DescripciónThymidylate Synthase (TS) (EC 188.8.131.52) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Host Species: Mouse
Clone: TS 106
Species Reactivity: Human. Others not known.
Epitope: Not determined
Immunogen: Recombinant human TS enzyme
Molecular Weight: 36kDa
Positive Control: 5-FU-resistant cell cancer lines or colon CA
Cellular Localization: Nuclear and cytoplasmic
- Western Blotting
- Immunoprecipitation (Native verified)
- Flow Cytometry
USA: RUO; Int'l: RUO
|Thymidylate Synthase Ab-1|
|Recombinant human TS enzyme|
|Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot|