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Thrombospondin (TSP) Ab-3, Mouse Monoclonal Antibody,Lab Vision™ Epredia™

Provide accurate, reproducible results with the Epredia™ Thrombospondin (TSP) Ab-3, Mouse Monoclonal Antibody.

Marca:  Epredia MS-420-PABX

Detalles adicionales : Peso : 1.00000kg

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Código de producto. 12691387

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Descripción

Descripción

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

Host Species: Mouse

Clone: C6.7

Isotype: IgG1

Species Reactivity: Human, Cow, Pig, Horse, Dog, Sheep and Rat. Others not known.

Epitope: Platelet- or cell-binding domain at the extreme C-terminus of TSP

Immunogen: Ca2+-replete, native purified human TSP from supernatant of thrombin-activated platelets

Molecular Weight: ∽450kDa (Nonreduced)

Cellular Localization: Secretory granules, Golgi complex, endoplasmic reticulum, extracellular matrix Ab-3 shows no cross-reaction with fibronectin, fibrinogen, and von Willebrand factor. It blocks TSP-mediated agglutination of fixed RBCs. It shows no effect on TSP-mediated agglutination of fixed, activated platelets. It inhibits both thrombin- and A23187-induced aggregation of washed, live (not fixed) platelets without affecting the secretion of serotonin. It inhibits adhesion of melanoma G361 cells to TSP. It blocks binding of C-terminal domain to Integrin-Associated Protein (IAP)/CD47.

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting (Nonreduced only)
  • Immunofluorescence
  • Immunoprecipitation (Native verified)
  • Electron Microscopy
  • Flow Cytometry
  • Blocks Binding of TSP-1 to IAP/CD47

Note:

USA: RUO; Int'l: RUO

Especificaciones

Especificaciones

Thrombospondin (TSP) Ab-3
Monoclonal
1mg/mL
Mouse
200 μL
Angiogenesis
Bovine, Canine, Equine, Human, Porcine, Rat, Sheep
IgG1
Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot
C6.7
Unconjugated
Ca2plus-replete, native purified human TSP from supernatant of thrombin-activated platelets
RUO
Primary
Concentrated
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