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Invitrogen™ TGFBR2 Recombinant Human Protein

Easily screen for kinase binding. Invitrogen™ TGFBR2 Recombinant Human Protein fusion protein consists of the catalytic domain of transforming growth factor beta receptor 2 (TGFBR2) and glutathione S-transferase (GST) tag. It is validated in the LanthaScreen™ Eu Kinase Binding Assay.

Marca:  Invitrogen™ PV6122

Detalles adicionales : Peso : 0.00900kg

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Código de producto. 11300872

  • 632.00€ / cada uno
Fecha estimada de envío: 11-04-2024
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Descripción

Descripción

The LanthaScreen™ Eu Kinase Binding Assay is a TR-FRET assay that lets you measure inhibitor binding to non-activated kinases, perform simple off-rate measurements and makes simple the study of type III (allosteric) inhibitors.

The LanthatScreen™ Eu Kinase Binding Assay is easy to optimize and run. The assay uses a simple mix-and-read format with a single one-hour incubation and no development steps. Simultaneous binding of an Alexa Fluor™ conjugate or tracer” to a tagged kinase is detected by addition of a europium-labeled anti-tag antibody, in this case anti-GST. Simultaneous binding of the tracer and antibody to the kinase results in a high degree of fluorescence resonance energy transfer (FRET), while displacement of the tracer with a kinase inhibitor results in a loss of FRET.

  • Compatible and validated with the LanthaScreen™ Eu Kinase Binding Assay
  • Expressed in insect cells
  • GST tagged for use with Eu-labeled GST antibody
  • No special measures were taken to activate this kinase

TGFBR2 for the LanthaScreen Kinase Binding Assay
Transforming Growth Factor, beta receptor 2 (TGFBR2) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. (TGFBR2 Aliases: AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII).

This insect cell-expressed recombinant fusion protein of the TGFBR2 catalytic domain and GST tag has been validated in the LanthaScreen™ Eu Kinase Binding Assay with the Tracer 178 and Eu-labeled GST Antibody reagents.

Especificaciones

Especificaciones

NP_003233
50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.02% NP-40, 2mM DTT and 50% glycerol.
70.3kDa
10μg
N-Terminal
TGFBR2
Human
GST Tag
Kinases & Inhibitors
Serine/Threonine Kinases
Kinase Assay, Enzyme and Protein Activity Assay, Industrial and Applied Science, Kinase Assay, Kinase Biology, Pharma and Biopharma, Protein Assays and Analysis, Protein Biology, Target and Lead Identification and Validation
7048
Purified
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
Truncated
STKR Kinase Family
Recombinant
Baculovirus
Frozen
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