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STK4 Mouse anti-Human, Mouse, Rat, Clone: 2G11C1, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 66663-1-IG-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16818755

  • 319.00€ / 150 microlitros

Envío estimado: 20-10-2021

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Descripción

Descripción

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
Especificaciones

Especificaciones

STK4
2G11C1
Unconjugated
STK4
Liquid
Stk4
STK4 Fusion Protein Ag17738
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q13043, Q9JI11
DKFZp686A2068, KRS2, MST 1, MST1, serine/threonine kinase 4, STE20 like kinase MST1, STK4, YSK3
Mouse
IgG2a
150 μL
-20°C
Primary
311622, 58231, 6789
Videos
SDS
Documentos
Certificados