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SPIB Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 15768-1-AP-20UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16815094

  • 109.00€ / 20 microlitros

Envío estimado: 22-10-2021

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Descripción

Descripción

Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5′-GAGGAA-3′) that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.
Especificaciones

Especificaciones

SPIB
0.25 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O35906, Q01892, Q5EBA3
SPI B, SPIB, Transcription factor Spi B
Rabbit
IgG
20 μL
-20°C
Primary
272382, 499146, 6689
Western Blot, Immunoprecipitation
Unconjugated
SPIB
Liquid
Spib
SPIB Fusion Protein Ag8404
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Rat, Human, Mouse
Videos
SDS
Documentos
Certificados