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SIGIRR Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 27828-1-AP-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16815855

  • 319.00€ / 150 microlitros

Envío estimado: 22-10-2021

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Descripción

Descripción

SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
Especificaciones

Especificaciones

SIGIRR
0.33 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q6IA17, Q9JLZ8
SIGIRR, TIR8, Toll/interleukin 1 receptor 8
Rabbit
IgG
150 μL
-20°C
Primary
24058, 59307
Western Blot
Unconjugated
SIGIRR
Liquid
SIGIRR
SIGIRR Fusion Protein Ag25850
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Videos
SDS
Documentos
Certificados