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SHH Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

140.00€ - 399.00€

Especificaciones

Antígeno SHH
Concentración 0.4 mg/mL
Aplicaciones Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Clasificación Polyclonal
Conjugado Unconjugated
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
16830275
Ver documentos Detalles de la promoción
Proteintech
20697-1-AP-20UL
20 μL
140.00€
20 microlitros
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Ahorre hasta 
»
Fecha estimada de envío: 17-04-2024
para ver el stock
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16820275
Ver documentos Detalles de la promoción
Proteintech
20697-1-AP-150UL
150 μL
399.00€
150 microlitros
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 17-04-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

Sonic Hedgehog, which is expressed only during embryogenesis, is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the Sonic Hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. In addition, it is thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.
Especificaciones

Especificaciones

SHH
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
Rabbit
Human, Mouse, Rat
Q15465, Q62226, Q63673
20423, 29499, 6469
Peptide
Primary
-20°C
SHH
0.4 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
HHG 1, HHG1, HLP3, HPE3, MCOPCB5, SHH, SMMCI, Sonic hedgehog protein, TPT, TPTPS
SHH
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documentos

Documentos

Product Certifications