SAPAP4 Polyclonal Antibody, Invitrogen™

Descripción

Immunogen sequence: GVQVEDDWRS SVPSHSMSSR RDTDSDTQDA NDSSCKSSER SLPDCTPHPN SISIDAGPRQ APKIAQIKRN LSYGDNSDPA L Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 98%.

SAP90/PSD-95-associated protein 4 (SAPAP4, also known as DLGAP4) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP4 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP4 mRNA is targeted to cell bodies in a similar manner to SAPAP1 and -2, whereas SAPAP3 mRNA is detected mainly in cell bodies.