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RTF1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 12170-1-AP-20UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16819723

  • 109.00€ / 20 microlitros

Envío estimado: 29-10-2021

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Descripción

Descripción

Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
Especificaciones

Especificaciones

RTF1
0.4 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
A2AQ19, Q92541
CDG1N, GTL7, KIAA0252, RTF1
Rabbit
IgG
20 μL
-20°C
Primary
23168, 366169, 76246
Immunoprecipitation, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RTF1
Liquid
Rtf1
RTF1 Fusion Protein Ag2812
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human, Rat
Videos
SDS
Documentos
Certificados