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RRAS Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 11647-1-AP-20UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16818873

  • 109.00€ / 20 microlitros

Envío estimado: 02-11-2021

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Descripción

Descripción

The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signal pathways control such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. These GTPases function as molecular switches that control eukaryotic cell function by cycling between two interconvertible forms, a GDP-bound inactive form and a GTP-bound active form. The binding of GTP leads to a conformational change in the downstream effector-binding domain of the G-protein. The small GTPases are monomeric G-proteins with molecular masses over the range 20-30 kDa. Ras is attached to the cell membrane by prenylation. Mutations in the Ras family of proto-oncogenes (comprising H-Ras, N-Ras and K-Ras) are very common, being found in 20% to 30% of all human tumours. The frequency of RAS mutations is among the highest for any gene in human cancer. K-ras mutations occur frequently in non-small-cell lung, colorectal, and pancreatic carcinomas; H-ras mutations are common in bladder, kidney, and thyroid carcinomas; N-ras mutations are found in melanoma, hepatocellular carcinoma, and hematologic maligcies.
Especificaciones

Especificaciones

RRAS
0.25 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
D3Z8L7, P10301, P10833
p23, Ras related protein R Ras, RRAS
Rabbit
IgG
20 μL
-20°C
Primary
20130, 361568, 6237
Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
RRAS
Liquid
Rras
RRAS Fusion Protein Ag2246
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Rat, Mouse, Human
Videos
SDS
Documentos
Certificados