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  5. Tocris Bioscience™ Zosuquidar Trihydrochloride

Tocris Bioscience™ Zosuquidar Trihydrochloride

Product Code. 18790278
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18790278 10 mg 10mg
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Product Code. 18790278 Supplier Tocris Bioscience™ Supplier No. 5456/10

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Description

High affinity P-gp inhibitor

Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material Zosuquidar trihydrochloride
CAS 167465-36-3
Synonym (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride
Quantity 10 mg
Solubility Soluble to 50mM in DMSO
Molecular Formula C32H31F2N3O2·3HCl
Formula Weight 636.99
Physical Form Solid
Product Type Bioactive Small Molecule
Purity 97%

Research Use Only. Not For Human or Veterinary Use

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