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PYGL Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 55429-1-AP-20UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16816895

  • 109.00€ / 20 microlitros

Envío estimado: 22-10-2021

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Descripción

Descripción

This antibody is specific to PYGL. It has no cross reaction to PYGM and PYGB.

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Especificaciones

Especificaciones

PYGL
0.51 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P06737, Q9ET01
GSD6, phosphorylase, glycogen, liver, PYGL
Rabbit
IgG
20 μL
-20°C
Primary
110095, 5836
Western Blot, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
Unconjugated
PYGL
Liquid
PYGL
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Videos
SDS
Documentos
Certificados