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PSD95/DLG4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 20665-1-AP-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16820245

  • 319.00€ / 150 microlitros

Envío estimado: 21-10-2021

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Descripción

Descripción

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
Especificaciones

Especificaciones

PSD95/DLG4
0.33 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P31016, P78352, Q62108
Disks large homolog 4, DLG4, PSD 95, PSD95, SAP 90, SAP90, Synapse associated protein 90
Rabbit
IgG
150 μL
-20°C
Primary
13385, 1742, 29495
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
DLG4
Liquid
DLG4
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Videos
SDS
Documentos
Certificados