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POLR3B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 16574-1-AP-20UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16816234

  • 140.00€ / 20 microlitros
Fecha estimada de envío: 17-04-2024
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Descripción

Descripción

Members of the Protein kinase C (PKC) family of serine/threonine protein kinases are grouped by their activation mechanism. Classical or conventional PKCs (PKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol. The Ca2+ insensitive novel PKCs (PKCs epsilon-, delta-, theta- and eta) are also activated by diacylglycerol and phosphatidylserine. The atypical PKCs (PKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbolesters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. PKCs are involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP.
Especificaciones

Especificaciones

POLR3B
Polyclonal
Unconjugated
POLR3B
C128, POLR3B, RNA polymerase III subunit C2, RPC2
Rabbit
Antigen Affinity Chromatography
RUO
362858, 55703, 70428
-20°C
Liquid
Western Blot
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P59470, Q9NW08
Polr3b
POLR3B Fusion Protein Ag9856
20 μL
Primary
Mouse, Rat, Human
Antibody
IgG
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