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PHAX Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marca: Proteintech 16481-1-AP-20UL
Detalles adicionales : Peso : 0.00010kg
Descripción
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.Especificaciones
PHAX | |
Polyclonal | |
Unconjugated | |
PHAX | |
PHAX, RNUXA | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
286917, 51808, 56698 | |
-20°C | |
Liquid |
Immunocytochemistry, Western Blot, Immunofluorescence | |
0.15 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q63068, Q9H814, Q9JJT9 | |
Phax | |
PHAX Fusion Protein Ag9602 | |
20 μL | |
Primary | |
Rat, Mouse, Human | |
Antibody | |
IgG |