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PAK4/6/7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 12460-1-AP-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16820184

  • 319.00€ / 150 microlitros

Envío estimado: 29-10-2021

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Descripción

Descripción

The antibody can recognize PAK4/6/7. PAK4/6/7 belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily.

PAK4 is highly expressed in prostate, testis and colon. PAK4 interacts tightly with GTP-bound but not GDP-bound CDC42 and weakly with RAC. PAK4 phosphorylates and autophosphorylates and also activates the JNK pathway. PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction. PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
Especificaciones

Especificaciones

PAK4/6/7
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O96013, Q3ULB5, Q8BTW9, Q8C015, Q9NQU5, Q9P286
KIAA1264, p21 activated kinase 5, p21 activated kinase 7, PAK 5, PAK 7, PAK5, PAK7
Rabbit
IgG
150 μL
-20°C
Primary
10298, 214230, 241656, 292756, 296078, 311450, 56924, 57144, 70584
Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
PAK4
Liquid
Pak4, PAK5, PAK6, Pak7
PAK4/6/7 Fusion Protein Ag3127
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Videos
SDS
Documentos
Certificados