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P27/KIP1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 25614-1-AP-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16814185

  • 319.00€ / 150 microlitros

Envío estimado: 27-10-2021

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Descripción

Descripción

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichiometry. p27 Kip1 has a molecular weight of approximately 27 kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
Especificaciones

Especificaciones

P27/KIP1
0.33 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P46414, P46527
CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27, P27; KIP1, P27KIP1
Rabbit
IgG
150 μL
-20°C
Primary
1027, 12576
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
CDKN1B
Liquid
CDKN1B
P27; KIP1 Fusion Protein Ag22582
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Videos
SDS
Documentos
Certificados