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OTUD7B Mouse anti-Human, Clone: 2C12D9, Proteintech
Mouse Monoclonal Antibody
Marca: Proteintech 66276-1-IG-150UL
Detalles adicionales : Peso : 0.00010kg
Descripción
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ′Lys-48′-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ′Lys-11′, ′Lys-48′ or ′Lys-63′- linked polyubiquitin chains. In vitro, has preference for ′Lys- 11′-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.Especificaciones
OTUD7B | |
Monoclonal | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q6GQQ9 | |
OTUD7B | |
OTUD7B Fusion Protein Ag10513 | |
150 μL | |
Primary | |
Human | |
Antibody | |
IgG2b |
Western Blot | |
2C12D9 | |
Unconjugated | |
OTUD7B | |
CEZANNE, OTU domain containing 7B, OTUD7B, ZA20D1, Zinc finger protein Cezanne | |
Mouse | |
Protein A | |
RUO | |
56957 | |
-20°C | |
Liquid |