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OPA1 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1B2D8, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 66583-1-IG-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16818595

  • 319.00€ / 150 microlitros

Envío estimado: 02-11-2021

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Descripción

Descripción

OPA1 is a dynamin-related GTPase that is critical for the maintece of mitochondrial morphology and mtDNA. The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous domit trait that causes reduced visual clarity and sometimes blindness. The disease usually begins in childhood and increases in severity throughout the life of affected individuals. Usually, this phenotype is attributed to the degeneration of optic nerve fibers. Interestingly, the same type of nerve degeneration seems to be partially causative of certain schizophrenia characteristics. OPA1 dysfunction also seems to be implicated in this case; mitochondrial networks associated with critical nerves seem to link schizophrenia and OPA1. The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1.
Especificaciones

Especificaciones

OPA1
1B2D8
Unconjugated
OPA1
Liquid
Opa1
OPA1 Fusion Protein Ag26868
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Porcine, Rat
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O60313, P58281, Q2TA68
KIAA0567, largeG, MGM1, NTG, OPA1, Optic atrophy protein 1
Mouse
IgG2b
150 μL
-20°C
Primary
100522705, 171116, 4976, 74143
Videos
SDS
Documentos
Certificados