missing translation for 'onlineSavingsMsg'
Learn More

Invitrogen™ Novex™ VEGF Human ELISA Kit

Quantifies natural or recombinant human Vascular Endothelial Growth Factor (VEGF) in serum, plasma, buffered solution, or cell culture medium

Marca:  Invitrogen™ KHG0112

Detalles adicionales : Peso : 0.21000kg

 Ver más versiones de este producto

Código de producto. 10436293

  • 794.00€ / 192 tests


Stock EU 9
Añadir a la cesta

Descripción

Descripción

VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.
Especificaciones

Especificaciones

P15692
Biotin
7422
4 hr.
Pre-coated 96 well plate, Standard, Standard Dilution Buffer, Biotinylated Detection Antibody, Streptavidin-HRP, HRP Diluent, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
ELISA
RUO
Plasma, Serum, Supernatants
Plasma (50μL), Serum (50μL), Supernatants (50μL)
1 hr 20 min
Human
8.1%
HRP
23.4-1500 pg/mL
Colorimetric Detection
Pre-coated plate, standard, detector antibody, Streptavidin-HRP, diluents, wash buffer, chromogen, stop solution, and plate covers.
Colorimetric Microplate Reader
VEGF
192 assays
<5 pg/mL
50μL
2-8°C
4 hr
VEGFA
4.7%
Videos

For Research Use Only. Not for use in diagnostic procedures.