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Invitrogen™ Novex™ IFN-γ Human ELISA Kit

Each ready-to-use kit ELISA kit is validated for sensitivity, specificity, precision, and lot-to-lot consistency.

Marca:  Invitrogen™ KHC4021

Detalles adicionales : Peso : 0.25000kg

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Código de producto. 10786513

  • 532.00€ / 96 tests


Stock EU 6
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Descripción

Descripción

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
Especificaciones

Especificaciones

P01579
Biotin
3458
2.75 hr.
Pre-coated 96 well plate, Standard, Standard Dilution Buffer, Biotinylated Detection Antibody, Streptavidin-HRP, HRP Diluent, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
ELISA Kit
RUO
Serum,Supernatant
Serum,50 μL|Supernatant,50μL
1 hr 20 min
Human
6.0%
HRP
15.6-1000 pg/mL
Colorimetric Detection
Pre-coated plate, standard, detector antibody, Streptavidin-HRP, diluents, wash buffer, chromogen, stop solution, and plate covers.
Colorimetric Microplate Reader
IFN-γ
96 Tests
<4 pg/mL
50μL
2-8°C
2 hr 45 min
IFNG
5.5%
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For Research Use Only. Not for use in diagnostic procedures.