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Thermo Scientific™ Lab Vision™ MUC-1 Ab-5, Hamster Monoclonal Antibody

Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.

116.93€ - 583.45€

Especificaciones

Antígeno MUC-1 Ab-5
Clon MH1; same as CT2
Aplicaciones Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clasificación Monoclonal
Conjugado Unconjugated
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Productos 6
Código de producto Marca Formulación Cantidad. Precio Cantidad y disponibilidad  
Código de producto Marca Formulación Cantidad. Precio Cantidad y disponibilidad  
12628606 Ver documentos Thermo Scientific™
HM-1630-P0
Purified Ab with BSA and Azide 100μL 116.93€
100 microlitros Ver productos alternativos
Ahorre hasta 
»
Fecha de envío estimada
del proveedor 04-11-2019
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12638606 Ver documentos Thermo Scientific™
HM-1630-P1
Purified Ab with BSA and Azide 500μL 325.34€
500 microlitros Ver productos alternativos
Ahorre hasta 
»
Fecha de envío estimada
del proveedor 06-11-2019
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12618606 Ver documentos Thermo Scientific™
HM-1630-P
Purified Ab with BSA and Azide 1mL 543.14€
1 ml Ver productos alternativos
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»
Consúltenos : 902 239 303 
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12648606 Ver documentos Thermo Scientific™
HM-1630-P1ABX
Ab without BSA/Azide (Frozen) 100μL 357.62€
100 microlitros Ver productos alternativos
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»
Consúltenos : 902 239 303 
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12658606 Ver documentos Thermo Scientific™
HM-1630-PABX
Ab without BSA/Azide (Frozen) 200μL 583.45€
200 microlitros Ver productos alternativos
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»
Consúltenos : 902 239 303 
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12688606 Ver documentos Thermo Scientific™
HM-1630-R7
Ready-to-use for IHC (UVLP) 7mL 280.21€
7 ml Ver productos alternativos
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»
Consúltenos : 902 239 303 
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Descripción

Descripción

Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation.

Host Species: Hamster

Clone: MH1 (CT2)

Isotype: IgG

Species Reactivity: Human and Mouse. Others not tested.

Epitope: aa 239-255

Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC-1

Molecular Weight: 14-28kDa

Positive Control: MCF-7 cells; Breast CA

Cellular Localization: Cytoplasmic and membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Especificaciones

Especificaciones

MUC-1 Ab-5
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
RUO
Primary
IgG
MH1; same as CT2
Monoclonal
Hamster
Cancer and Tumor Biology
A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1