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STEMCELL Technologies Mouse Recombinant IL-13

Interleukin 13

Marca:  STEMCELL Technologies 78030.1

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17189391

  • 272.65€ / 10 microgramos
Fecha estimada de envío: 18-11-2022
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Descripción

Descripción

  • Interleukin 13 (IL-13) is a type I cytokine, and signals through type I cytokine receptors to activate JAK/STAT and IRS-1/IRS-2 pathways
  • IL-13 is produced by T cells and innate lymphoid cells (Pulendran & Artis) and it inhibits production of pro-inflammatory cytokines, prostaglandins, and reactive oxygen and nitrogen species by monocytes and macrophages (Hershey)
  • Unlike human B cells, IL-13 has no effect on mouse B cell development and function
  • IL-13 promotes eosinophil survival, activation, and recruitment, and also activates mast cells (Hershey)
  • IL-13 regulates gastrointestinal parasite expulsion, airway hyperresponsiveness, allergic inflammation, tissue eosinophilia, goblet cell hyperplasia, intracellular parasitism, tissue remodeling, tumor cell growth, and fibrosis
  • IL-13 induces hypercontractility of smooth muscles by directly acting on the muscle cells as well as the enteric nerves (Wynn)
Especificaciones

Especificaciones

Interleukin-13, NC30
≥95%
10 μg
B Cells; Hematopoietic Stem and Progenitor Cells; Monocytes
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