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STEMCELL Technologies Mouse Recombinant IL-13
Interleukin 13
Marca: STEMCELL Technologies 78030.1
Detalles adicionales : Peso : 0.00110kg
Descripción
- Interleukin 13 (IL-13) is a type I cytokine, and signals through type I cytokine receptors to activate JAK/STAT and IRS-1/IRS-2 pathways
- IL-13 is produced by T cells and innate lymphoid cells (Pulendran & Artis) and it inhibits production of pro-inflammatory cytokines, prostaglandins, and reactive oxygen and nitrogen species by monocytes and macrophages (Hershey)
- Unlike human B cells, IL-13 has no effect on mouse B cell development and function
- IL-13 promotes eosinophil survival, activation, and recruitment, and also activates mast cells (Hershey)
- IL-13 regulates gastrointestinal parasite expulsion, airway hyperresponsiveness, allergic inflammation, tissue eosinophilia, goblet cell hyperplasia, intracellular parasitism, tissue remodeling, tumor cell growth, and fibrosis
- IL-13 induces hypercontractility of smooth muscles by directly acting on the muscle cells as well as the enteric nerves (Wynn)
Especificaciones
| Interleukin-13, NC30 | |
| 10 μg | |
| B Cells; Hematopoietic Stem and Progenitor Cells; Monocytes | |
| ≥95% |