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ACROBiosystems Mouse Glypican 2 / GPC2 Protein, His Tag
Marca: ACROBiosystems GP2-M52H5-1mg
Detalles adicionales : Peso : 0.00010kg
Descripción
Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.6 kDa. The protein migrates as 60-106 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.Especificaciones
NP_766000.1 | |
1 mg | |
His 22 - Ser 556 | |
Glypican 2,GPC2 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |
60.6 kDa | |
Mouse Glypican 2, His Tag (GP2-M52H5) is expressed from human 293 cells (HEK293). It contains AA His 22 - Ser 556 (Accession # Q8BKV1-1). | |
-20°C | |
Glypican 2 | |
Mouse | |
PBS, pH7.4 | |
HEK293 | |
Bio-Markers and CD Antigens |