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LRRK2 G2019S Full Length Protein
LRRK2 G2019S Full Length Protein
Marca: Invitrogen A15200
Detalles adicionales : Peso : 0.00900kg
Descripción
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.Related Links:
Especificación
NP_940980.3 | |
Pharma and biopharma, protein assays and analysis, target and lead identification and validation | |
LRRK2 G2019S Full Length Protein | |
10μg | |
For research use only. Not for use in diagnostic procedures | |
AURA17, DARDARIN, PARK8, RIPK7, ROCO2 | |
LRRK2 G2019S Full Length was pre-diluted in enzyme dilution buffer and assayed in 20mM Tris (pH 7.5), 10mM MgCl2, 1mM EGTA, 1mM Na3VO4, 5mM β-glycerophosphate, 2mM DTT, 0.02% Triton™ X-100, 100μM ATP, 250μM ERM (LRRKtide) peptide substrate (RLGRDKYKTLRQIRQ) (PV5093) and trace [32P]-γ-ATP for 10 minutes at 30°C | |
Mammalian | |
LRRK2 G2019S Full Length Protein | |
Human |
0.22mg/mL | |
288kDa | |
90% by SDS-PAGE | |
–68 to –85°C | |
1 Each | |
LRRK2 G2019S Full Length Protein | |
Kinase assay | |
LRRK | |
120nmoles of phosphate transferred to ERM (LRRKtide) peptide substrate (RLGRDKYKTLRQIRQ) (PV5093) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 2.08μg/mL | |
DYKDDDDK |
For Research Use Only. Not for use in diagnostic procedures.