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LRP2 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

140.00€ - 399.00€

Especificaciones

Antígeno LRP2
Concentración 0.32 mg/mL
Aplicaciones Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin)
Clasificación Polyclonal
Conjugado Unconjugated
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
16819184
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Proteintech
19700-1-AP-20UL
20 μL
140.00€
20 microlitros
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Fecha estimada de envío: 17-04-2024
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16809184
Ver documentos Detalles de la promoción
Proteintech
19700-1-AP-150UL
150 μL
399.00€
150 microlitros
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 17-04-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

This antibody is specific to LRP2 and detects endogenous LRP2 with an apparent molecular weight 280 kDa, which is smaller than the predicted molecular weight (522 kDa) and probably represent a proteolytic fragment of the large glycoprotein.

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
Especificaciones

Especificaciones

LRP2
Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin)
Unconjugated
Rabbit
Human
P98164
4036
Peptide
Primary
-20°C
LRP2
0.32 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
DBS, Fx1a, Glycoprotein 330, gp330, LRP 2, LRP2, Megalin
LRP2
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documentos

Documentos

Product Certifications