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LIMPII Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 27102-1-AP-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16815395

  • 399.00€ / 150 microlitros
Fecha estimada de envío: 17-04-2024
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Descripción

Descripción

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
Especificaciones

Especificaciones

LIMPII
Polyclonal
Unconjugated
SCARB2
AMRF, CD36 antigen like 2, CD36L2, HLGP85, LGP85, LIMP II, limp2, LIMPII, Lysosome membrane protein 2, Lysosome membrane protein II, SCARB2, SR BII
Rabbit
Antigen Affinity Chromatography
RUO
12492, 950
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.3 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O35114, Q14108
SCARB2
LIMPII Fusion Protein Ag25908
150 μL
Primary
Human, Mouse
Antibody
IgG
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