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Epredia™ Lab Vision™ p57Kip2 Ab-7 Rabbit Polyclonal Antibody with BSA and azide
Deliver accurate, reproducible results with the Epredia™ p57Kip2 Ab-7, Rabbit Polyclonal Antibody.
Marca: Epredia™ RB-1637-P1ABX
Detalles adicionales : Peso : 0.00170kg
Descripción
p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.Host Species: Rabbit
Isotype: IgG
Species Reactivity: Human, Cow and Mouse. Others not known.
Epitope: Near C-terminus
Immunogen: A synthetic peptide from human p57Kip2 protein
Molecular Weight: 57kDa
Positive Control: Colon CA or placenta
Cellular Localization: Nuclear
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting (Not suitable)
Note:
USA: RUO; Int'l: RUO
Especificaciones
| p57superscriptKip2superscript Ab-7 | |
| Polyclonal | |
| Unconjugated | |
| A synthetic peptide from human p57superscriptKip2superscript protein | |
| RUO | |
| Primary | |
| Concentrated |
| Immunohistochemistry (Paraffin) | |
| 1mg/mL | |
| Rabbit | |
| 500 μL | |
| Cancer and Tumor Biology | |
| Bovine, Human, Mouse | |
| IgG |