Epredia™ Lab Vision™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1 Mouse Monoclonal Antibody, 200µg/mL, biotinylated, BSA and azide
Epredia™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.
Marca: Epredia™ MS-470-P0
Detalles adicionales : Peso : 0.00170kg
DescripciónCancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.
Host Species: Mouse
Clone: MT 3.1
Species Reactivity: Human. Also reacts weakly with Mouse, Rat and Hamster. Others not known.
Epitope: aa 8-221
Immunogen: Purified recombinant human MGMT protein
Molecular Weight: 25kDa
Positive Control: Raji cells, Colon CA
Cellular Localization: Nuclear and cytoplasmic
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Flow Cytometry
USA: RUO; Int'l: RUO
|MGMT (O-methylguanine-DNA methyltransferase) Ab-1|
|Purified Ab with BSA and Azide|
|Immunohistochemistry (Paraffin), Western Blot|
|Purified recombinant human MGMT protein|
|Hamster, Human, Murine, Rat|