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Epredia™ Lab Vision™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1 Mouse Monoclonal Antibody, 200µg/mL, biotinylated, BSA and azide

Epredia™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.

Marca:  Epredia™ MS-470-P0

Detalles adicionales : Peso : 0.00170kg

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Código de producto. 12691527

  • 118.00€ / 100 microlitros

Fecha estimada de envío
21-06-2021

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Descripción

Descripción

Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.

Host Species: Mouse

Clone: MT 3.1

Isotype: IgG1

Species Reactivity: Human. Also reacts weakly with Mouse, Rat and Hamster. Others not known.

Epitope: aa 8-221

Immunogen: Purified recombinant human MGMT protein

Molecular Weight: 25kDa

Positive Control: Raji cells, Colon CA

Cellular Localization: Nuclear and cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Especificaciones

Especificaciones

MGMT (O-methylguanine-DNA methyltransferase) Ab-1
Monoclonal
200μg/mL
Purified Ab with BSA and Azide
Murine
IgG1
RUO
Primary
Monoclonal
Immunohistochemistry (Paraffin), Western Blot
MT 3.1
Unconjugated
Concentrated
Purified recombinant human MGMT protein
100μL
Enzyme
Primary
Hamster, Human, Murine, Rat
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