Epredia™ Lab Vision™ Epidermal Growth Factor Receptor/EGFR Ab-1, Mouse Monoclonal Antibody

Descripción

EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Mouse

Clone: 528

Isotype: IgG2a

Species Reactivity: Human and Dog. Does not react with mouse and rat. Others not known.

Epitope: Extracellular domain

Immunogen: Purified EGFR from A431 cells

Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)

Positive Control: A431 cells

Cellular Localization: Membrane

Recommended for:

• Western Blotting (Not suitable)
• Affinity Purification
• Blocks EGF/TGFα-induced Activation of EGFR
• Inhibits Binding of EGFR Ab-2 (clone 225) to EGFR
• Inhibits Proliferation of A431 Cells
• Arrests Tumor Growth in vivo
• Immunoprecipitation (Native only)
• Flow Cytometry

Note:

USA: RUO; Int'l: RUO