Epredia™ Lab Vision™ Cytokeratin 5 Rabbit Monoclonal Antibody

Descripción

Twenty human cytokeratins are divided into acidic (pI<5.7) and basic (pI>6.0) subfamilies. Members of the acidic and basic subfamilies are found together in pairs. The composition of cytokeratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of cytokeratins as markers in cancer research and tumor identification. Point mutations in cytokeratin-5 gene may cause Epidermolysis Bullosa Simplex and Dowling-Degos disease. cytokeratin-5 is expressed in most epithelioid and biphasic mesotheliomas, thymoma, squamous and other carcinomas. It is related to cytokeratin-6.

Host Species: Rabbit

Clone: EP1601Y

Isotype: IgG

Species Reactivity: Human. Others not known.

Immunogen: A synthetic peptide corresponding to residues on the C-terminus of human CK5

Molecular Weight: 59 kDa

Positive Control: Mesothelioma

Cellular Localization: Cytoplasmic

Recommended for:

• Immunohistochemistry (Formalin/paraffin)