Epredia™ Lab Vision™ CD21 Ab-2, Mouse Monoclonal Antibody

Descripción

CD21, also known as CR2, C3d receptor and EBV receptor, is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNα. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

Host Species: Mouse

Clone: 2G9

Isotype: IgG2a

Species Reactivity: Human. Others not tested.

Epitope: Extracellular domain

Immunogen: Recombinant protein encoding the external domain of human CD21

Molecular Weight: 140 kDa

Positive Control: Tonsil

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)