CD117/c-Kit/SCF-Receptor Rabbit Polyclonal Antibody, Epredia™

Descripción

Recognizes a protein of 145kDa, which is identified as CD117/p145kit. This rabbit polyclonal antibody does not interfere with the binding of SCF to c-kit. It precipitates both the unoccupied as well as the occupied form of c-kit. The binding of the stem cell factor (SCF) to the c-kit-encoded receptor tyrosine kinase (Type III) stimulates a variety of biochemical responses that culminate in cellular proliferation, migration, or survival. C-kit plays an important role in hematopoiesis, melanogenesis, and gametogenesis. This antibody is excellent for staining of formalin-fixed, paraffin-embedded tissues.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Dog. Others not tested

Epitope: Cytoplasmic domain

Immunogen: A synthetic peptide from the cytoplasmic domain of human CD117/c-kit protein

Molecular Weight: 145 kDa

Positive Control: Stromal tumor, skin or tonsil

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)