Epredia™ Lab Vision™ β-Catenin Rabbit Monoclonal Antibody

Descripción

The catenins (α, β and γ) are ubiquitously expressed cytoplasmic proteins associated with E-cadherin at cellular junctions. β-catenin also binds to N-cadherin and co-immunoprecipitates with APC. Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between α-actinin and α-catenin. Increased tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing cellular adhesion. Mutations in the catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas.

Host Species: Rabbit

Clone: E247

Species Reactivity: Human. Others not known.

Immunogen: A synthetic peptide derived from near the N-terminus of human β-catenin

Molecular Weight: 92 kDa

Positive Control: Breast CA

Cellular Localization: Cell Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)