Epredia™ Lab Vision™ β-Catenin Rabbit Monoclonal Antibody
Ensure accurate and reproducible results in immunohistochemistry applications with this antibody, part of a comprehensive antibody portfolio.
Marca: Epredia™ RM-2101-RQ
Detalles adicionales : Peso : 0.02000kg
DescripciónThe catenins (α, β and γ) are ubiquitously expressed cytoplasmic proteins associated with E-cadherin at cellular junctions. β-catenin also binds to N-cadherin and co-immunoprecipitates with APC. Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between α-actinin and α-catenin. Increased tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing cellular adhesion. Mutations in the catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas.
Host Species: Rabbit
Species Reactivity: Human. Others not known.
Immunogen: A synthetic peptide derived from near the N-terminus of human β-catenin
Molecular Weight: 92 kDa
Positive Control: Breast CA
Cellular Localization: Cell Membrane
- Immunohistochemistry (Formalin/paraffin)
|A synthetic peptide derived from near the N-terminus of human beta-catenin|
|Cancer and Tumor Biology|