CA19-9/Sialyl Lewisa (GI Tumor Marker) Ab-1 Mouse Monoclonal Antibody, Epredia™

Descripción

Mucin glycoprotein is a sialyl Lewis^a structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewis^a and/or Lewis^b blood group antigens. In normal tissues, sialyl Lewis^a antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings.

Host Species: Mouse

Clone: 121SLE

Isotype: IgM

Species Reactivity: Human. Does not react with rat. Others not tested.

Immunogen: Mucins from ovarian cyst

Molecular Weight: >400kDa

Positive Control: Colon CA

Cellular Localization: Cytoplasmic

Recommended for:

• Immunohistochemistry (Formalin/paraffin)