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  7. KN-62, Thermo Scientific Chemicals

KN-62, Thermo Scientific Chemicals

Catalog Number p-7042411
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Cantidad:
1 mg
10 mg
Este artículo no se puede devolver. Vea la política de devoluciones
127191-97-3
C38H35N5O6S2
721.85
MFCD00083180
RJVLFQBBRSMWHX-UHFFFAOYNA-N
s-4-2-n-methylisoquinoline-5-sulfonamido-3-oxo-3-4-phenylpiperazin-1-yl propyl phenyl isoquinoline-5-sulfonate, unii-63hm46xpow, chembl28324, 63hm46xpow, 1-n,o-bis 5-isoquinolinesulfonyl-n-methyl-l-tyrosyl-4-phenylpiperazine, s-5-isoquinolinesulfonic acid 4-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl ester, 4-2s-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl isoquinolinesulfonic acid ester, 4-2s-2-n-methylisoquinoline-5-sulfonamido-3-oxo-3-4-phenylpiperazin-1-yl propyl phenyl isoquinoline-5-sulfonate, 5-isoquinolinesulfonic acid, 4-2s-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl ester
5312126
isoquinolina-5-sulfonato de [4-[(2S)-2-[isoquinolin-5-ilsulfonil(metil)amino]-3-oxo-3-(4-fenilpiperazin-1-il)propil]fenil]
CN(C(CC1=CC=C(OS(=O)(=O)C2=C3C=CN=CC3=CC=C2)C=C1)C(=O)N1CCN(CC1)C1=CC=CC=C1)S(=O)(=O)C1=C2C=CN=CC2=CC=C1
Este artículo no se puede devolver. Vea la política de devoluciones
127191-97-3
C38H35N5O6S2
721.85
MFCD00083180
RJVLFQBBRSMWHX-UHFFFAOYNA-N
s-4-2-n-methylisoquinoline-5-sulfonamido-3-oxo-3-4-phenylpiperazin-1-yl propyl phenyl isoquinoline-5-sulfonate, unii-63hm46xpow, chembl28324, 63hm46xpow, 1-n,o-bis 5-isoquinolinesulfonyl-n-methyl-l-tyrosyl-4-phenylpiperazine, s-5-isoquinolinesulfonic acid 4-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl ester, 4-2s-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl isoquinolinesulfonic acid ester, 4-2s-2-n-methylisoquinoline-5-sulfonamido-3-oxo-3-4-phenylpiperazin-1-yl propyl phenyl isoquinoline-5-sulfonate, 5-isoquinolinesulfonic acid, 4-2s-2-5-isoquinolinylsulfonyl methylamino-3-oxo-3-4-phenyl-1-piperazinyl propyl phenyl ester
5312126
isoquinolina-5-sulfonato de [4-[(2S)-2-[isoquinolin-5-ilsulfonil(metil)amino]-3-oxo-3-(4-fenilpiperazin-1-il)propil]fenil]
CN(C(CC1=CC=C(OS(=O)(=O)C2=C3C=CN=CC3=CC=C2)C=C1)C(=O)N1CCN(CC1)C1=CC=CC=C1)S(=O)(=O)C1=C2C=CN=CC2=CC=C1

Descripción

Inhibe el calcio/calmodulina quinasa II de forma potente y específica.

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
Se utiliza como un potente y selectivo inhibidor de CaMKII. El KN-62 ha demostrado inhibición potente y selectiva de la proteína quinasa II dependiente de Ca2+/calmodulina (CaMKII; Ki=0,9 μM) que provoca la detención de las células en la fase S. En las células HEK-293 que expresan la adenilciclasa tipo III (III-AC), 10 μM de KN-62 bloquearon la fosforilación CaMKII de III-AC, e inhibieron las oscilaciones de Ca2+ estimuladas por hormonas. Además, KN-62 es un potente antagonista no competitivo en el receptor P2X7 (IC50 = 15 nM).

Solubilidad
Soluble en 45 % (p/v) aq 2-hidroxipropil-β-ciclodextrina (0,93 mg/ml), metanol (10 mg/ml), DMSO (12 mg/ml), cloroformo (20 mg/ml), etanol (∼1 mg/ml), 1:2 DMF:PBS (pH 7,2) (∼0,3 mg/ml) y DMF y DMSO (∼30 mg/ml).

Notas
Almacenar en un lugar fresco. Mantener dentro de un recipiente bien cerrado y en un lugar seco y bien ventilado. Temperatura de almacenamiento recomendada: - 20 °C. Manténgase alejado de agentes oxidantes fuertes.
TRUSTED_SUSTAINABILITY
Nombre del producto químico o material KN-62
Punto de fusión 65°C to 67°C
Color Amarillo
Fórmula lineal NH2(CH2)10NH2
Cantidad 1 mg
Información de solubilidad Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.93mg/ml),methanol (10mg/ml),DMSO (12mg/ml),chloroform (20mg/ml),ethanol (∽1mg/ml),1:2 DMF:PBS (pH 7.2) (∽0.3mg/ml),and DMF & DMSO (∽30mg/ml).
Formula Weight (peso de la fórmula) 721.84
Forma física Polvo

RUO – Research Use Only

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