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Invitrogen™ KIT [T670E] Recombinant Human Protein

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Recombinant human KIT T670E (544-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Marca:  Invitrogen™ PV6315

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15408963

  • 7490.00€ / 1 miligramo
Fecha estimada de envío: 23-04-2024
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Descripción

Descripción

KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Especificaciones

Especificaciones

Enzyme and Protein Activity Assay, Industrial and Applied Science, Kinase Assay, Kinase Biology, Kinase Proteins and Expression Reagents, Pharma and Biopharma, Protein Assays and Analysis, Protein Biology, Target and Lead Identification and Validation
75.3kDa
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
aa 544-end
Recombinant
50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol
1mg
PBT, SCFR, CD117
Human
GST Tag
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