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JAK2 Recombinant Human Protein, JH1 and JH2 Domains

JAK2 Recombinant Human Protein, JH1 and JH2 Domains

Marca:  Invitrogen PV4393

Detalles adicionales : Peso : 0.00900kg

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Código de producto. 11515026

  • 784.00€ / 10 microgramos


Fecha de envío estimada
del proveedor 03-01-2019
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Descripción

Descripción

JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains both the JH1 (catalytic) and JH2 (pseudokinase) domains of JAK2.
Especificación

Especificación

NP_004963
Pharma and biopharma, protein assays and analysis, target and lead identification and validation
JAK2 Recombinant Human Protein
10μg
For research use only. Not for use in diagnostic procedures
Cytoplasmic tyrosine kinase
JAK2 Recombinant Human Protein
Kinase assay
Baculovirus
Amino acids 532-1132
390nmoles of phosphate transferred to AXLtide peptide substrate (KKSRGDYMTMQIG) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 2.08μg/mL
GST Tag
0.32mg/mL
97.8kDa
90% by SDS-PAGE
–80°C
1 Each
JAK2 JH1 JH2
JAK2 JH1 JH2 was pre-diluted in enzyme dilution buffer and assayed in 25mM HEPES (pH 7.5), 10mM MgCl2, 0.5mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2.5mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL AXLtide peptide substrate (KKSRGDYMTMQIG) and trace [32P]-γ-ATP for 10 minutes at 30°C
Kinase and inhibitors
JAK
JAK2 Recombinant Human Protein
Human
Videos

For Research Use Only. Not for use in diagnostic procedures.